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off-target activity) of AMG 925 is about 50-fold as evaluated by comparison of its growth-inhibiting activity in RB-positive (RB+) and RB-negative (RB-) non- acute myeloid leukemia (AML) cancer cell lines
and selective pan-PIM kinase inhibitor
Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe
this agent binds weakly to the vinca-binding site
It has antitumor activity
Bay 55-9837 TFA EG1-OTs off-target activity) of AMG 925Bay 55 9837 TFA is a potent and highly selective agonist of VPAC2, with a Kd of 0. 65 nM. Bay 55 9837 TFA may be a useful therapy for the research of type 2 diabetes. Product information Molecular Weight: 3856. 27 Formula: C169H271F3N52O48 Chemical Name: 3 [(1 {[1 ({1 [(1 {[1 ({1 [(5 amino 1 {[1 ({1 [(1 {[1 ({5 amino 1 [(5 amino 1 {[1 ({1 [(1 {[1 ({1 [(5 amino 1 {[1 ({5 amino 1 [(4 carbamimidamido 1 {[1 carbamoyl 2 (4
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