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InChi: InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28
Formula: C13H14Cl3N7O4
Pharmacology of basimglurant (RO4917523
The (Z)-isomer has been consigned the name BMS-205912
20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H
PF-06463922 5109 HCl InChi: InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28Lorlatinib, also known as PF 06463922, is an orally available, ATP competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C ros oncogene 1 (Ros1), with potential antineoplastic activity. Upon administration, ALK ROS1 inhibitor PF 06463922 binds to and inhibits both ALK and ROS1 kinases. The kinase inhibition leads to disruption of ALK and ROS1 mediated signaling and eventually inhibits tumor cell growth in ALK and
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