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PubMed Central PMCID: PMC4697154
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
SJ000291942 causes an increase in bmp2b and szl expression
75 nM and 18 nM in SupT1 cells
potent and selective inhibitor of glycogen synthase kinase 3β (GSK3β) with an IC50 ~7 nM
WHI-P258 - CAS# 21561-09-1 60187 PubMed Central PMCID: PMC4697154WHI P258, CAS No. 21561 09 1, is a Janus kinase 3 inhibitor. WHI P131 may provide the basis for the design of new treatment strategies against acute lymphoblastic leukemia, the most common form of childhood cancer. Product information CAS Number: 21561 09 1 Molecular Weight: 281. 31 Formula: C16H15N3O2 Synonym: WHI P258 WHI P 258 WHIP 258 WHI P 258 Chemical Name: 6,7 Dimethoxy N phenylquinazolin 4 amine Smiles: COC1=CC2=NC=NC(NC3C=CC=CC=3)=C2C=C1OC
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